Projects

• Data Trust Association Biomedical Research Data State of Saxony-Anhalt [01.01.2022 to 31.12.2024]

• Independent parahydrogen-induced two-phase hyperpolarizer for ultra-low field and ultra-high field MR (2P-PHIP) [01.01.2022 to 31.12.2024]
• Construction of an LED unit for light-induced hyperpolarization of physiological substances [02.01.2018 to 31.12.2023].

Completed projects

• Development of molecular MR temperature probes
• Fluorinated boron clusters in cell culture
• Parahydrogen-induced nuclear spin hyperpolarization of fluorinated substrates - standard PHIP
• Parahydrogen-induced nuclear spin hyperpolarization - studies using the SABRE method
• Enhancement of MR sensitivity of ¹⁹F biomarkers and PET-analogous ¹⁹F-labeled receptor ligands by para-hydrogen-induced polarization

Research focus

¹⁹F NMR spectroscopy and MR imaging

• Enhancement of MR signals by parahydrogen-induced hyperpolarization (PHIP: PASADENA, ALTADENA, SABRE) and photo-CIDNP
• Cell labeling with MR-sensitive fluorinated substances for non-invasive observation of cell migration in tumor treatment
• Temperature determination using fluorinated markers and MR spectroscopy
• Synthesis and characterization of new water-soluble fluorinated compounds

Viability measurements in cell culture

• Review of the toxicity and stability of organic compounds regarding their toxicity and stability on fibroblasts and melanoma cells